RapamycinFungusV1, Main, Exploration, bibRecord, 000678

Salmonella Overcomes Drug Resistance in Tumor through P-glycoprotein Downregulation.

Identifieur interne : 000678 ( Main/Exploration ); précédent : 000677; suivant : 000679

Salmonella Overcomes Drug Resistance in Tumor through P-glycoprotein Downregulation.

Auteurs : Chih-Jen Yang [Taïwan] ; Wen-Wei Chang [Taïwan] ; Song-Tao Lin [Taïwan] ; Man-Chin Chen [Taïwan] ; Che-Hsin Lee [Taïwan]

Source :

International journal of medical sciences [ 1449-1907 ] ; 2018.

RBID : pubmed:29725247

Descripteurs français

KwdFr :
- Animaux (MeSH), Association thérapeutique (MeSH), Fluorouracil (administration et posologie), Glycoprotéine P (génétique), Humains (MeSH), Membrane cellulaire (effets des médicaments et des substances chimiques), Membrane cellulaire (génétique), Microenvironnement tumoral (effets des médicaments et des substances chimiques), Multirésistance aux médicaments (génétique), Mélanome expérimental (anatomopathologie), Mélanome expérimental (microbiologie), Mélanome expérimental (traitement médicamenteux), Protéines proto-oncogènes c-akt (génétique), Ribosomal Protein S6 Kinases, 70-kDa (génétique), Régulation de l'expression des gènes tumoraux (génétique), Salmonella (génétique), Salmonella (pathogénicité), Salmonelloses (anatomopathologie), Salmonelloses (génétique), Salmonelloses (microbiologie), Souris (MeSH), Sérine-thréonine kinases TOR (génétique).
MESH :
- administration et posologie : Fluorouracil.
- anatomopathologie : Mélanome expérimental, Salmonelloses.
- effets des médicaments et des substances chimiques : Membrane cellulaire, Microenvironnement tumoral.
- génétique : Glycoprotéine P, Membrane cellulaire, Multirésistance aux médicaments, Protéines proto-oncogènes c-akt, Ribosomal Protein S6 Kinases, 70-kDa, Régulation de l'expression des gènes tumoraux, Salmonella, Salmonelloses, Sérine-thréonine kinases TOR.
- microbiologie : Mélanome expérimental, Salmonelloses.
- pathogénicité : Salmonella.
- traitement médicamenteux : Mélanome expérimental.
- Animaux, Association thérapeutique, Humains, Souris.

English descriptors

KwdEn :
- ATP Binding Cassette Transporter, Subfamily B, Member 1 (genetics), Animals (MeSH), Cell Membrane (drug effects), Cell Membrane (genetics), Combined Modality Therapy (MeSH), Drug Resistance, Multiple (genetics), Fluorouracil (administration & dosage), Gene Expression Regulation, Neoplastic (genetics), Humans (MeSH), Melanoma, Experimental (drug therapy), Melanoma, Experimental (microbiology), Melanoma, Experimental (pathology), Mice (MeSH), Proto-Oncogene Proteins c-akt (genetics), Ribosomal Protein S6 Kinases, 70-kDa (genetics), Salmonella (genetics), Salmonella (pathogenicity), Salmonella Infections (genetics), Salmonella Infections (microbiology), Salmonella Infections (pathology), TOR Serine-Threonine Kinases (genetics), Tumor Microenvironment (drug effects).
MESH :
- chemical , administration & dosage : Fluorouracil.
- chemical , genetics : ATP Binding Cassette Transporter, Subfamily B, Member 1, Proto-Oncogene Proteins c-akt, Ribosomal Protein S6 Kinases, 70-kDa, TOR Serine-Threonine Kinases.
- drug effects : Cell Membrane, Tumor Microenvironment.
- drug therapy : Melanoma, Experimental.
- genetics : Cell Membrane, Drug Resistance, Multiple, Gene Expression Regulation, Neoplastic, Salmonella, Salmonella Infections.
- microbiology : Melanoma, Experimental, Salmonella Infections.
- pathogenicity : Salmonella.
- pathology : Melanoma, Experimental, Salmonella Infections.
- Animals, Combined Modality Therapy, Humans, Mice.

Abstract

Chemotherapy is one of effective methods for the treatment of tumor. Patients often develop drug resistance after chemotherapic cycles. Salmonella has potential as antitumor agent. Salmonella used in tandem with chemotherapy had additive effects, providing a rationale for using tumor-targeting Salmonella in combination with conventional chemotherapy. To improve the efficacy and safety of Salmonella, a further understanding of Salmonella interactions with the tumor microenvironment is required. The presence of plasma membrane multidrug resistance protein P-glycoprotein (P-gp) is highly relevant for the success of chemotherapy. Following Salmonella infection, dose-dependent downregulation of P-gp expressions were examined. Salmonella significantly decreased the efflux capabilities of P-gp, as based on the influx of Rhodamine 123 assay. In addition, Salmonella significant reduced the protein express the expression levels of phosph-protein kinase B (P-AKT), phosph-mammalian targets of rapamycin (P-mTOR), and phosph-p70 ribosomal s6 kinase (P-p70s6K) in tumor cells. The Salmonella-induced downregulation of P-gp was rescued by transfection of cells with active P-AKT. Our results demonstrate that Salmonella in tumor sites leads to decrease the expression of P-gp and enhances the combination of Salmonella and 5-Fluorouracil therapeutic effects.

DOI: 10.7150/ijms.23285
PubMed: 29725247
PubMed Central: PMC5930458

Affiliations:

Taïwan

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000562
to stream Main, to step Curation: 000562

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en"><i>Salmonella</i>
 Overcomes Drug Resistance in Tumor through P-glycoprotein Downregulation.</title>
<author><name sortKey="Yang, Chih Jen" sort="Yang, Chih Jen" uniqKey="Yang C" first="Chih-Jen" last="Yang">Chih-Jen Yang</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Department of Internal Medicine, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University, Kaohsiung</wicri:regionArea>
<wicri:noRegion>Kaohsiung</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung</wicri:regionArea>
<wicri:noRegion>Kaohsiung</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Faculty of Medicine, Department of Respiratory Therapy, College of Medicine, Kaohsiung Medical University, Taiwan.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Faculty of Medicine, Department of Respiratory Therapy, College of Medicine, Kaohsiung Medical University</wicri:regionArea>
<wicri:noRegion>Kaohsiung Medical University</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chang, Wen Wei" sort="Chang, Wen Wei" uniqKey="Chang W" first="Wen-Wei" last="Chang">Wen-Wei Chang</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biomedical Sciences, College of Medical Science and Technology, Chung Shan Medical University, Taichung, Taiwan.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Department of Biomedical Sciences, College of Medical Science and Technology, Chung Shan Medical University, Taichung</wicri:regionArea>
<wicri:noRegion>Taichung</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Department of Medical Research, Chung Shan Medical University Hospital, Taichung, Taiwan.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Department of Medical Research, Chung Shan Medical University Hospital, Taichung</wicri:regionArea>
<wicri:noRegion>Taichung</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lin, Song Tao" sort="Lin, Song Tao" uniqKey="Lin S" first="Song-Tao" last="Lin">Song-Tao Lin</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biological Sciences, National Sun Yat-sen University, Kaohsiung, Taiwan.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Department of Biological Sciences, National Sun Yat-sen University, Kaohsiung</wicri:regionArea>
<wicri:noRegion>Kaohsiung</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chen, Man Chin" sort="Chen, Man Chin" uniqKey="Chen M" first="Man-Chin" last="Chen">Man-Chin Chen</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biological Sciences, National Sun Yat-sen University, Kaohsiung, Taiwan.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Department of Biological Sciences, National Sun Yat-sen University, Kaohsiung</wicri:regionArea>
<wicri:noRegion>Kaohsiung</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lee, Che Hsin" sort="Lee, Che Hsin" uniqKey="Lee C" first="Che-Hsin" last="Lee">Che-Hsin Lee</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biological Sciences, National Sun Yat-sen University, Kaohsiung, Taiwan.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Department of Biological Sciences, National Sun Yat-sen University, Kaohsiung</wicri:regionArea>
<wicri:noRegion>Kaohsiung</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 404, Taiwan.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 404</wicri:regionArea>
<wicri:noRegion>Taichung 404</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2018">2018</date>
<idno type="RBID">pubmed:29725247</idno>
<idno type="pmid">29725247</idno>
<idno type="doi">10.7150/ijms.23285</idno>
<idno type="pmc">PMC5930458</idno>
<idno type="wicri:Area/Main/Corpus">000562</idno>
<idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000562</idno>
<idno type="wicri:Area/Main/Curation">000562</idno>
<idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000562</idno>
<idno type="wicri:Area/Main/Exploration">000562</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en"><i>Salmonella</i>
 Overcomes Drug Resistance in Tumor through P-glycoprotein Downregulation.</title>
<author><name sortKey="Yang, Chih Jen" sort="Yang, Chih Jen" uniqKey="Yang C" first="Chih-Jen" last="Yang">Chih-Jen Yang</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Department of Internal Medicine, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University, Kaohsiung</wicri:regionArea>
<wicri:noRegion>Kaohsiung</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung</wicri:regionArea>
<wicri:noRegion>Kaohsiung</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Faculty of Medicine, Department of Respiratory Therapy, College of Medicine, Kaohsiung Medical University, Taiwan.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Faculty of Medicine, Department of Respiratory Therapy, College of Medicine, Kaohsiung Medical University</wicri:regionArea>
<wicri:noRegion>Kaohsiung Medical University</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chang, Wen Wei" sort="Chang, Wen Wei" uniqKey="Chang W" first="Wen-Wei" last="Chang">Wen-Wei Chang</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biomedical Sciences, College of Medical Science and Technology, Chung Shan Medical University, Taichung, Taiwan.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Department of Biomedical Sciences, College of Medical Science and Technology, Chung Shan Medical University, Taichung</wicri:regionArea>
<wicri:noRegion>Taichung</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Department of Medical Research, Chung Shan Medical University Hospital, Taichung, Taiwan.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Department of Medical Research, Chung Shan Medical University Hospital, Taichung</wicri:regionArea>
<wicri:noRegion>Taichung</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lin, Song Tao" sort="Lin, Song Tao" uniqKey="Lin S" first="Song-Tao" last="Lin">Song-Tao Lin</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biological Sciences, National Sun Yat-sen University, Kaohsiung, Taiwan.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Department of Biological Sciences, National Sun Yat-sen University, Kaohsiung</wicri:regionArea>
<wicri:noRegion>Kaohsiung</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chen, Man Chin" sort="Chen, Man Chin" uniqKey="Chen M" first="Man-Chin" last="Chen">Man-Chin Chen</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biological Sciences, National Sun Yat-sen University, Kaohsiung, Taiwan.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Department of Biological Sciences, National Sun Yat-sen University, Kaohsiung</wicri:regionArea>
<wicri:noRegion>Kaohsiung</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lee, Che Hsin" sort="Lee, Che Hsin" uniqKey="Lee C" first="Che-Hsin" last="Lee">Che-Hsin Lee</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biological Sciences, National Sun Yat-sen University, Kaohsiung, Taiwan.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Department of Biological Sciences, National Sun Yat-sen University, Kaohsiung</wicri:regionArea>
<wicri:noRegion>Kaohsiung</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 404, Taiwan.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 404</wicri:regionArea>
<wicri:noRegion>Taichung 404</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">International journal of medical sciences</title>
<idno type="eISSN">1449-1907</idno>
<imprint><date when="2018" type="published">2018</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>ATP Binding Cassette Transporter, Subfamily B, Member 1 (genetics)</term>
<term>Animals (MeSH)</term>
<term>Cell Membrane (drug effects)</term>
<term>Cell Membrane (genetics)</term>
<term>Combined Modality Therapy (MeSH)</term>
<term>Drug Resistance, Multiple (genetics)</term>
<term>Fluorouracil (administration & dosage)</term>
<term>Gene Expression Regulation, Neoplastic (genetics)</term>
<term>Humans (MeSH)</term>
<term>Melanoma, Experimental (drug therapy)</term>
<term>Melanoma, Experimental (microbiology)</term>
<term>Melanoma, Experimental (pathology)</term>
<term>Mice (MeSH)</term>
<term>Proto-Oncogene Proteins c-akt (genetics)</term>
<term>Ribosomal Protein S6 Kinases, 70-kDa (genetics)</term>
<term>Salmonella (genetics)</term>
<term>Salmonella (pathogenicity)</term>
<term>Salmonella Infections (genetics)</term>
<term>Salmonella Infections (microbiology)</term>
<term>Salmonella Infections (pathology)</term>
<term>TOR Serine-Threonine Kinases (genetics)</term>
<term>Tumor Microenvironment (drug effects)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux (MeSH)</term>
<term>Association thérapeutique (MeSH)</term>
<term>Fluorouracil (administration et posologie)</term>
<term>Glycoprotéine P (génétique)</term>
<term>Humains (MeSH)</term>
<term>Membrane cellulaire (effets des médicaments et des substances chimiques)</term>
<term>Membrane cellulaire (génétique)</term>
<term>Microenvironnement tumoral (effets des médicaments et des substances chimiques)</term>
<term>Multirésistance aux médicaments (génétique)</term>
<term>Mélanome expérimental (anatomopathologie)</term>
<term>Mélanome expérimental (microbiologie)</term>
<term>Mélanome expérimental (traitement médicamenteux)</term>
<term>Protéines proto-oncogènes c-akt (génétique)</term>
<term>Ribosomal Protein S6 Kinases, 70-kDa (génétique)</term>
<term>Régulation de l'expression des gènes tumoraux (génétique)</term>
<term>Salmonella (génétique)</term>
<term>Salmonella (pathogénicité)</term>
<term>Salmonelloses (anatomopathologie)</term>
<term>Salmonelloses (génétique)</term>
<term>Salmonelloses (microbiologie)</term>
<term>Souris (MeSH)</term>
<term>Sérine-thréonine kinases TOR (génétique)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Fluorouracil</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>ATP Binding Cassette Transporter, Subfamily B, Member 1</term>
<term>Proto-Oncogene Proteins c-akt</term>
<term>Ribosomal Protein S6 Kinases, 70-kDa</term>
<term>TOR Serine-Threonine Kinases</term>
</keywords>
<keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Fluorouracil</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Mélanome expérimental</term>
<term>Salmonelloses</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Cell Membrane</term>
<term>Tumor Microenvironment</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Melanoma, Experimental</term>
</keywords>
<keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Membrane cellulaire</term>
<term>Microenvironnement tumoral</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Cell Membrane</term>
<term>Drug Resistance, Multiple</term>
<term>Gene Expression Regulation, Neoplastic</term>
<term>Salmonella</term>
<term>Salmonella Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Glycoprotéine P</term>
<term>Membrane cellulaire</term>
<term>Multirésistance aux médicaments</term>
<term>Protéines proto-oncogènes c-akt</term>
<term>Ribosomal Protein S6 Kinases, 70-kDa</term>
<term>Régulation de l'expression des gènes tumoraux</term>
<term>Salmonella</term>
<term>Salmonelloses</term>
<term>Sérine-thréonine kinases TOR</term>
</keywords>
<keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Mélanome expérimental</term>
<term>Salmonelloses</term>
</keywords>
<keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Melanoma, Experimental</term>
<term>Salmonella Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Salmonella</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Salmonella</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Melanoma, Experimental</term>
<term>Salmonella Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Mélanome expérimental</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Combined Modality Therapy</term>
<term>Humans</term>
<term>Mice</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Association thérapeutique</term>
<term>Humains</term>
<term>Souris</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Chemotherapy is one of effective methods for the treatment of tumor. Patients often develop drug resistance after chemotherapic cycles. <i>Salmonella</i>
 has potential as antitumor agent. <i>Salmonella</i>
 used in tandem with chemotherapy had additive effects, providing a rationale for using tumor-targeting <i>Salmonella</i>
 in combination with conventional chemotherapy. To improve the efficacy and safety of <i>Salmonella</i>
, a further understanding of <i>Salmonella</i>
 interactions with the tumor microenvironment is required. The presence of plasma membrane multidrug resistance protein P-glycoprotein (P-gp) is highly relevant for the success of chemotherapy. Following <i>Salmonella</i>
 infection, dose-dependent downregulation of P-gp expressions were examined. <i>Salmonella</i>
 significantly decreased the efflux capabilities of P-gp, as based on the influx of Rhodamine 123 assay. In addition, <i>Salmonella</i>
 significant reduced the protein express the expression levels of phosph-protein kinase B (P-AKT), phosph-mammalian targets of rapamycin (P-mTOR), and phosph-p70 ribosomal s6 kinase (P-p70s6K) in tumor cells. The <i>Salmonella</i>
-induced downregulation of P-gp was rescued by transfection of cells with active P-AKT. Our results demonstrate that <i>Salmonella</i>
 in tumor sites leads to decrease the expression of P-gp and enhances the combination of <i>Salmonell</i>
a and 5-Fluorouracil therapeutic effects.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">29725247</PMID>
<DateCompleted><Year>2018</Year>
<Month>09</Month>
<Day>17</Day>
</DateCompleted>
<DateRevised><Year>2018</Year>
<Month>12</Month>
<Day>02</Day>
</DateRevised>
<Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Electronic">1449-1907</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>15</Volume>
<Issue>6</Issue>
<PubDate><Year>2018</Year>
</PubDate>
</JournalIssue>
<Title>International journal of medical sciences</Title>
<ISOAbbreviation>Int J Med Sci</ISOAbbreviation>
</Journal>
<ArticleTitle><i>Salmonella</i>
 Overcomes Drug Resistance in Tumor through P-glycoprotein Downregulation.</ArticleTitle>
<Pagination><MedlinePgn>574-579</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.7150/ijms.23285</ELocationID>
<Abstract><AbstractText>Chemotherapy is one of effective methods for the treatment of tumor. Patients often develop drug resistance after chemotherapic cycles. <i>Salmonella</i>
 has potential as antitumor agent. <i>Salmonella</i>
 used in tandem with chemotherapy had additive effects, providing a rationale for using tumor-targeting <i>Salmonella</i>
 in combination with conventional chemotherapy. To improve the efficacy and safety of <i>Salmonella</i>
, a further understanding of <i>Salmonella</i>
 interactions with the tumor microenvironment is required. The presence of plasma membrane multidrug resistance protein P-glycoprotein (P-gp) is highly relevant for the success of chemotherapy. Following <i>Salmonella</i>
 infection, dose-dependent downregulation of P-gp expressions were examined. <i>Salmonella</i>
 significantly decreased the efflux capabilities of P-gp, as based on the influx of Rhodamine 123 assay. In addition, <i>Salmonella</i>
 significant reduced the protein express the expression levels of phosph-protein kinase B (P-AKT), phosph-mammalian targets of rapamycin (P-mTOR), and phosph-p70 ribosomal s6 kinase (P-p70s6K) in tumor cells. The <i>Salmonella</i>
-induced downregulation of P-gp was rescued by transfection of cells with active P-AKT. Our results demonstrate that <i>Salmonella</i>
 in tumor sites leads to decrease the expression of P-gp and enhances the combination of <i>Salmonell</i>
a and 5-Fluorouracil therapeutic effects.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Yang</LastName>
<ForeName>Chih-Jen</ForeName>
<Initials>CJ</Initials>
<AffiliationInfo><Affiliation>Department of Internal Medicine, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Faculty of Medicine, Department of Respiratory Therapy, College of Medicine, Kaohsiung Medical University, Taiwan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chang</LastName>
<ForeName>Wen-Wei</ForeName>
<Initials>WW</Initials>
<AffiliationInfo><Affiliation>Department of Biomedical Sciences, College of Medical Science and Technology, Chung Shan Medical University, Taichung, Taiwan.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Medical Research, Chung Shan Medical University Hospital, Taichung, Taiwan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lin</LastName>
<ForeName>Song-Tao</ForeName>
<Initials>ST</Initials>
<AffiliationInfo><Affiliation>Department of Biological Sciences, National Sun Yat-sen University, Kaohsiung, Taiwan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chen</LastName>
<ForeName>Man-Chin</ForeName>
<Initials>MC</Initials>
<AffiliationInfo><Affiliation>Department of Biological Sciences, National Sun Yat-sen University, Kaohsiung, Taiwan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lee</LastName>
<ForeName>Che-Hsin</ForeName>
<Initials>CH</Initials>
<AffiliationInfo><Affiliation>Department of Biological Sciences, National Sun Yat-sen University, Kaohsiung, Taiwan.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 404, Taiwan.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2018</Year>
<Month>03</Month>
<Day>09</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>Australia</Country>
<MedlineTA>Int J Med Sci</MedlineTA>
<NlmUniqueID>101213954</NlmUniqueID>
<ISSNLinking>1449-1907</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D020168">ATP Binding Cassette Transporter, Subfamily B, Member 1</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 2.7.1.1</RegistryNumber>
<NameOfSubstance UI="C546842">MTOR protein, human</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 2.7.1.1</RegistryNumber>
<NameOfSubstance UI="D058570">TOR Serine-Threonine Kinases</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 2.7.11.1</RegistryNumber>
<NameOfSubstance UI="D051057">Proto-Oncogene Proteins c-akt</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 2.7.11.1</RegistryNumber>
<NameOfSubstance UI="D038762">Ribosomal Protein S6 Kinases, 70-kDa</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>U3P01618RT</RegistryNumber>
<NameOfSubstance UI="D005472">Fluorouracil</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D020168" MajorTopicYN="N">ATP Binding Cassette Transporter, Subfamily B, Member 1</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002462" MajorTopicYN="N">Cell Membrane</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D003131" MajorTopicYN="N">Combined Modality Therapy</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018432" MajorTopicYN="N">Drug Resistance, Multiple</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005472" MajorTopicYN="N">Fluorouracil</DescriptorName>
<QualifierName UI="Q000008" MajorTopicYN="Y">administration & dosage</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015972" MajorTopicYN="N">Gene Expression Regulation, Neoplastic</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008546" MajorTopicYN="N">Melanoma, Experimental</DescriptorName>
<QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName>
<QualifierName UI="Q000382" MajorTopicYN="Y">microbiology</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D051057" MajorTopicYN="N">Proto-Oncogene Proteins c-akt</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D038762" MajorTopicYN="N">Ribosomal Protein S6 Kinases, 70-kDa</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012475" MajorTopicYN="N">Salmonella</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
<QualifierName UI="Q000472" MajorTopicYN="N">pathogenicity</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012480" MajorTopicYN="N">Salmonella Infections</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
<QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D058570" MajorTopicYN="N">TOR Serine-Threonine Kinases</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D059016" MajorTopicYN="N">Tumor Microenvironment</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">5-Fluorouracil</Keyword>
<Keyword MajorTopicYN="N">P-glycoprotein</Keyword>
<Keyword MajorTopicYN="N">Salmonella</Keyword>
<Keyword MajorTopicYN="N">combination therapy</Keyword>
<Keyword MajorTopicYN="N">tumor</Keyword>
</KeywordList>
<CoiStatement>Competing Interests: The authors have declared that no competing interest exists.</CoiStatement>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2017</Year>
<Month>10</Month>
<Day>11</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2018</Year>
<Month>02</Month>
<Day>14</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2018</Year>
<Month>5</Month>
<Day>5</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2018</Year>
<Month>5</Month>
<Day>5</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2018</Year>
<Month>9</Month>
<Day>18</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>epublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">29725247</ArticleId>
<ArticleId IdType="doi">10.7150/ijms.23285</ArticleId>
<ArticleId IdType="pii">ijmsv15p0574</ArticleId>
<ArticleId IdType="pmc">PMC5930458</ArticleId>
</ArticleIdList>
<ReferenceList><Reference><Citation>J Cell Biochem. 2016 May;117(5):1233-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26460589</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Oncotarget. 2015 May 10;6(13):11369-77</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25957417</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biochem Pharmacol. 2013 Aug 15;86(4):548-60</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23792120</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Oncotarget. 2015 Feb 20;6(5):2615-22</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25575815</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Environ Toxicol. 2014 Apr;29(4):363-70</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22331677</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Commun. 2016 Jul 25;7:12225</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27452236</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Oncotarget. 2016 Jan 5;7(1):374-85</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26517244</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Int J Med Sci. 2017 Sep 19;14 (12 ):1181-1188</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29104473</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Oncotarget. 2017 May 23;8(21):35048-35060</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28456782</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Am J Physiol Gastrointest Liver Physiol. 2008 Jun;294(6):G1392-400</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18403618</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Oncotarget. 2015 Nov 10;6(35):38308-26</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26515462</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Vaccine. 2011 Jan 17;29(4):728-36</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21095252</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell Cycle. 2016 Jul 2;15(13):1715-23</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27152859</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>BMC Pharmacol Toxicol. 2017 May 10;18(1):21</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28486985</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Appl Microbiol Biotechnol. 2012 Jan;93(2):517-23</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22120621</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Appl Microbiol Biotechnol. 2011 May;90(4):1381-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21360146</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Sci Rep. 2017 Aug 11;7(1):7972</Citation>
<ArticleIdList><ArticleId IdType="pubmed">28801675</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS One. 2016 Aug 08;11(8):e0160882</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27500926</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Oncotarget. 2016 Jun 21;7(25):37513-37523</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27175584</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Exp Biol Med (Maywood). 2012 Oct;237(10):1189-96</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23045719</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Oncotarget. 2016 Dec 27;7(52):85929-85936</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27835903</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS One. 2015 May 06;10 (5):e0125774</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25946033</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Clin Cancer Res. 2008 Mar 15;14(6):1905-12</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18347194</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Int J Med Sci. 2017 Sep 3;14 (11):1049-1053</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29104457</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Oncotarget. 2016 Mar 15;7(11):12783-90</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26859573</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Int J Cancer. 2013 Oct 15;133(8):1926-35</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23558669</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Oncotarget. 2014 Dec 15;5(23):12346-57</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25402324</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Ther. 2005 May;11(5):707-16</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15851009</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>Taïwan</li>
</country>
</list>
<tree><country name="Taïwan"><noRegion><name sortKey="Yang, Chih Jen" sort="Yang, Chih Jen" uniqKey="Yang C" first="Chih-Jen" last="Yang">Chih-Jen Yang</name>
</noRegion>
<name sortKey="Chang, Wen Wei" sort="Chang, Wen Wei" uniqKey="Chang W" first="Wen-Wei" last="Chang">Wen-Wei Chang</name>
<name sortKey="Chang, Wen Wei" sort="Chang, Wen Wei" uniqKey="Chang W" first="Wen-Wei" last="Chang">Wen-Wei Chang</name>
<name sortKey="Chen, Man Chin" sort="Chen, Man Chin" uniqKey="Chen M" first="Man-Chin" last="Chen">Man-Chin Chen</name>
<name sortKey="Lee, Che Hsin" sort="Lee, Che Hsin" uniqKey="Lee C" first="Che-Hsin" last="Lee">Che-Hsin Lee</name>
<name sortKey="Lee, Che Hsin" sort="Lee, Che Hsin" uniqKey="Lee C" first="Che-Hsin" last="Lee">Che-Hsin Lee</name>
<name sortKey="Lin, Song Tao" sort="Lin, Song Tao" uniqKey="Lin S" first="Song-Tao" last="Lin">Song-Tao Lin</name>
<name sortKey="Yang, Chih Jen" sort="Yang, Chih Jen" uniqKey="Yang C" first="Chih-Jen" last="Yang">Chih-Jen Yang</name>
<name sortKey="Yang, Chih Jen" sort="Yang, Chih Jen" uniqKey="Yang C" first="Chih-Jen" last="Yang">Chih-Jen Yang</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Bois/explor/RapamycinFungusV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000678 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000678 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Bois
   |area=    RapamycinFungusV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     pubmed:29725247
   |texte=   Salmonella Overcomes Drug Resistance in Tumor through P-glycoprotein Downregulation.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:29725247" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a RapamycinFungusV1

This area was generated with Dilib version V0.6.38.
Data generation: Thu Nov 19 21:55:41 2020. Site generation: Thu Nov 19 22:00:39 2020

	Serveur d'exploration sur la rapamycine et les champignons
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur la rapamycine et les champignons

Salmonella Overcomes Drug Resistance in Tumor through P-glycoprotein Downregulation.

Salmonella Overcomes Drug Resistance in Tumor through P-glycoprotein Downregulation.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki